Is there a pre-existing autoimmune dysfunction? Is there a history of prior orthopedic injury, DJD, OA, RA? Other immune-related adverse effects Three subtypes of inflammatory arthritis associated with checkpoint inhibitors: Polyarthritis similar to rheumatoid arthritis True reactive arthritis with conjunctivitis, urethritis, and oligoarthritis Subtype similar to seronegative spondyloarthritis with inflammatory back pain and predominantly larger
Read moreHas the patient noted any change in breathing? Does the patient feel short of breath? Does the patient note new dyspnea on exertion? Does the patient notice a new cough? Or a change in an existing cough? Have symptoms worsened? Are symptoms limiting ADLs? Associated symptoms? Fatigue Wheezing
Read moreIs the pulse oximetry low? Is it lower than baseline or compared with last visit? Is it low on exertion? Is there a pre-existing pulmonary autoimmune condition (i.e., sarcoidosis)? Is there a history of prior respiratory compromise (e.g., asthma, COPD, congestive heart failure)? Has the patient experienced other immune-related adverse effects?
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